Myesthenia Gravis

Myasthenia gravis (MG) is the most common disorder of neuromuscular transmission. The hallmark of the disorder is a fluctuating degree and variable combination of weakness in ocular, bulbar, limb, and respiratory muscles. Weakness is the result of an antibody-mediated, T-cell dependent immunologic attack directed at proteins in the postsynaptic membrane of the neuromuscular junction. There are two clinical forms of myasthenia: ocular and generalized. In ocular form, the weakness is limited to the eyelids and extraocular muscles. In generalized form, the weakness may also commonly affect ocular muscles, but it also involves a variable combination of bulbar, limb, and respiratory muscles. The Tensilon test and ice pack test are used to diagnose the case. The initial therapy for most patients with myasthenia gravis (MG) is an oral anticholinesterase medication.