Ectodermal dysplasia
The ectodermal dysplasias (EDs) comprise a large, heterogeneous group of inherited
disorders that are defined by primary defects in the development of 2 or more
tissues derived from embryonic ectoderm: the skin, hair, nails, eccrine glands,
and teeth. Parents often complain of fever not subsiding by antipyretics and
not sweating. Clinical examination reveals sparse, fair, brittle hair with
alopecia, and sparse or absent eyebrows and eyelashes. They often have nail
dystrophy and dental abnormality. Treatment consist of encouraging frequent
consumption of cool liquids to maintain adequate hydration and thermoregulation
and early dental evaluation and intervention and encouraging routine dental
hygiene.