Gangrene of limb

Gangrene of limb may be with oedema or without oedema. If it is oedematous mostly the cause is infective or venous obstruction. If the gangrene is not associated with oedema then the common causes are vasospastic or thrombo-embolic. Raynauds phenomenon could be due to collagen diseases, Burgerís disease, cold agglutinin, cryoglobulinaemia , neurogenic etc.