Pulseless disease (Takayasu arterteritis, aortic arch syndrome)
First described by Dr. Mikito Takayasu, a Japanese ophthalmologist in 1908 and subsequently named after him. It is a rare vasculitis of large vessels of unknown origin affecting from infancy to adults. In children often suspected when pulses are not felt during examination for other reasons because of nonspecific constitutional symptoms. Angiography or MRI shows multiple areas of stenosis and aneurysm. Detailed history reveals symptoms of ischaemia including abdominal pain, claudication and syncope. It is treated with corticosteroid in high doses.