This condition is due to the deficiency of thyroid hormone either congenital or acquired. It could be due to the deficiency of iodine , abnormality in thyroid gland or low thyroid stimulating hormone from hypothalamus. The affected child has the typical facial appearance as seen bellow. After two weeks of thyroid hormone there is drastic change in appearance. Often the treatment is continued for life long. Every neonate with prolonged jaundice should be investigated for hypothyroidism because mental retardation could be prevented.

             Before treatment                                                      After two weeks of treatment